Basic diagram of the insulin/IGFs system involved in growth and proliferation signaling. credit: Cell cycle (2022). DOI: 10.1080/15384101.2022.2108117
Studies show that insulin-like growth factor (IGF) plays a central role in the pathological growth of proliferative conditions such as cancer and can function as a resistance mechanism adopted by most solid cancers after therapeutic targeting of non-IGF signaling pathways.
Last week magazine Cell cycle published a review article titled Cell cycle control by insulin-like growth factor signaling: at the crossroads between cell growth and mitotic regulation. The work is based on many years of experience and collaboration of co-authors associated with the ISOPROG-Somatolink research network and the Sbarro Institute for Cancer Research and Molecular Medicine, part of the Sbarro Health Research Organization (SHRO), at Temple University in Philadelphia, together with the Arthur Riggs Diabetes Institute and the Scientific- by the Beckman Research Institute at City of Hope in Duarte, California.
According to the authors, “the article has been specifically designed for both those new to the field of IGF biology and established researchers focusing on pathway-driven molecular targeting.
“Overall, the review aims to clarify and functionally integrate established experimental findings and redirects readers to widely validated studies of this complex molecular system and its growth/mitotic cellular network.
“The analysis shows that strategies and solutions to co-target IGF signaling still represent an unmet goal in current cancer treatments. Therefore, a better understanding of IGF growth signaling/mitotic regulation remains a key goal for more effective cancer therapy.”
Pierluigi Scalia and others. Cell cycle control by insulin-like growth factor signaling: at the crossroads between cell growth and mitotic regulation, Cell cycle (2022). DOI: 10.1080/15384101.2022.2108117
Courtesy of Sbarro Health Research Organization (SHRO)
Citation: Molecular Medicine Review Reveals Role of IGFs in Cancer and Other Proliferative Diseases (2022, August 31) Retrieved August 31, 2022, from https://phys.org/news/2022-08-molecular-medicine-reveals-role- igf. html
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