EpiAge is different from cellular aging and telomere depletion. a, Measurement of EpiAge (DNAmAge) of whole skin, keratinocytes and fibroblasts from 14 healthy skin samples. The lack of samples between the ages of 1 and 40 reflects the hospitalization deficit of this demographic. b, DNA measurement 17 BCC and corresponding healthy skin. c, EpiAge cultured in vitro neonatal human skin keratinocytes (HDK) derived from foreskin. CPD, the total population has doubled. Representative of more than three experiments. d, EpiAges of primary human skin fibroblasts isolated from the skin of 14 healthy newborn donors and exposed to 20 Gy X-rays, transduced to express oncogenic ras or cultivation to replicative aging (Rep.Sen). e, estimation of telomere length (DNAmTL) of cells based on DNA methylation described in d. f, DNAmAge of primary neonatal skin fibroblasts transduced with blank vector (control) or hTERT-expressing vector (hTERT). The arrow and the letter “S” indicate the point at which the untreated control cells have become obsolete. Representative of two experiments. g, EpiAge adult HCAECs transduced with an empty vector (control) or a vector expressing hTERT. Representative of three experiments. Credit: The aging of nature (2022). DOI: 10.1038 / s43587-022-00220-0
A team of researchers from many institutions in the UK and US has investigated whether epigenetic aging is a manifestation of one or more signs of aging. In their article published in the journal The aging of naturethe group describes the exposure of human cells to three types of abuse and then testing them to see if the cells are aging epigenetically.
Over the past few years, some researchers who have focused on the science of aging have become proponents of what is described as epigenetic aging, in which some attributes of our body age at a rate that may not match ours. biological age. This has led to studies aimed at measuring the epigenetic age of humans (and other animals). DNA methylation clock, ostensibly as a means of circumventing them and allowing people to live longer. In this new effort, researchers studied signs of aging such as radiation exposure, replicated them, and tested the effects on the rate of epigenetic aging.
The work involved collecting tissue samples from 14 healthy people and dividing them into four groups. One group was exposed to a small dose of radiation, in another some properties of the cells were altered to become cancerous, and another group was subjected to induced aging. The fourth group was not disturbed. Each of the groups was a hallmark of aging. Exposure to radiation can, for example, alter the genome, leading to accelerated aging.
None of the tissue samples revealed changes in epigenetic aging. But researchers have found changes in how cells process energy – their ability to feel nutrients has been affected. This ability plays an important role in cell growth, reproduction and death. The researchers also found changes in mitochondrial activity and the number of stem cells in their samples. They suggest that epigenetic aging does not predict changes in aging and does not coincide with age-related changes in telomeres, a major indicator of aging in general.
Sylwia Kabacik et al, Relationship between epigenetic age and signs of aging in human cells, The aging of nature (2022). DOI: 10.1038 / s43587-022-00220-0
Steve Horvat and others, hours of DNA methylation for dogs and humans, Proceedings of the National Academy of Sciences (2022). DOI: 10.1073 / pnas.2120887119
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Citation: A study on whether epigenetic aging is a manifestation of one or more signs of aging (2022, May 25), obtained May 25, 2022 from https://phys.org/news/2022-05-epigenetic-aging-manifestation -hallmarks.html
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